Pomd11 Cannabinoids Are Neuroprotective in a Human Cell Culture Model of Parkinson’s Disease

of previous publications detailing SGCE mutation status and psychiatric disease. Inclusion criteria included: use of recognised MDS diagnostic criteria, a case control study design, SGCE status, and the use of standardised and validated psychiatric assessment tools. When data were pooled, these showed a significant association between SGCE mutations and psychiatric disease (p1⁄40.028), including obsessive-compulsive disorders, depression and generalised anxiety disorder. This association was further strengthened when inclusion criteria were relaxed to include details of psychiatric diagnoses obtained by clinical history or patient self-report (p1⁄40.012). This supports the view that psychiatric disorders form part of the MDS phenotype and that epsilon-sarcoglycan may have an important role to play.